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KMID : 1161420160190050481
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Journal of Medicinal Food
2016 Volume.19 No. 5 p.481 ~ p.485
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Effect of Artemisia dracunculus Administration on Glycemic Control, Insulin Sensitivity, and Insulin Secretion in Patients with Impaired Glucose Tolerance
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Villar Miriam Mendez-del
Puebla-Perez Ana M.
Sanchez-Pena Maria J.
Gonzalez-Ortiz Luis J.
Martinez-Abundis Esperanza
Gonzalez-Ortiz Manuel
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Abstract
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To evaluate the effect of Artemisia dracunculus on glycemic control, insulin sensitivity, and insulin secretion in patients with impaired glucose tolerance (IGT). A randomized, double blind, placebo-controlled clinical trial was performed in 24 patients with diagnosis of IGT. Before and after the intervention, glucose and insulin levels were measured every 30?min for 2?h after a 75-g dextrose load, along with glycated hemoglobin A1c (A1C) and lipid profile. Twelve patients received A. dracunculus (1000?mg) before breakfast and dinner for 90 days; the remaining 12 patients received placebo. Area under the curve (AUC) of glucose and insulin, total insulin secretion, first phase of insulin secretion, and insulin sensitivity were calculated. Wilcoxon signed-rank, Mann?Whitney U, and chi-square tests were used for statistical analyses. The institutional ethics committee approved the protocol. After A. dracunculus administration, there were significant decreases in systolic blood pressure (SBP; 120.0?±?11.3 vs. 113.0?±?11.2?mmHg, P?
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KEYWORD
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glucose, insulin, prediabetes, Russian tarragon
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